The Taoiseach will push for a review of the EU-Israel Association Agreement, following an Israeli attack on a UNIFIL watchtower in Lebanon.
Simon Harris will engage with other nations contributing to UN peacekeeping efforts to ensure better protection for troops.
Ukrainian President Volodymyr Zelensky will outline his 'victory plan' to EU leaders, with discussions focusing on fortifying Ukraine's energy and infrastructure ahead of winter.
Migration will also take centre stage, as several member states seek coordinated responses to the growing number of asylum seekers.