The Masterchef and restaurant critic had previously admitted that she was struggling in the jungle, ahead of the Touchdown of Terror trial.
"Unfortunately Grace Dent has left the show on medical grounds", a spokesperson for the Ant and Dec hosted ITV programme had stated. "She has been a great campmate and will be missed by her fellow celebrities and viewers alike".
The 50 year old had previously told campmate Josie Gibson last week, "I've had enough. I’ve completely had enough. I just want to go home".
She also added in the Bush Telegraph, "I haven’t got a lot left in me at the moment. I’m just keeping on a face for everybody".
Dent had been chosen to face the next trial alongside Gibson, Down The Tubes. It has since been confirmed that EastEnders' Danielle Harold will now take part in the trial alongside Gibson.