The former One Direction singer was performing at the venue for the second night running, as part of his 'Love On Tour'.
During the gig, a young Italian fan name Mattia held up a sign which read, “From Ono to Wembley: Help me come out".
Having spotted the sign, Harry Styles duly obliged, calling Mattia “officially gay, my boy”. The Adore You sing proceeded to spread a Pride flag out onto the stage.
“Congratulations Mattia, you are a free man", he added.
Check this out for yourselves below.