Lock began his career in 1993, starring alongside David Baddiel and Rob Newman for their TV show Newman and Baddiel In Pieces.
Lock also went on to win best live stand up at the British Comedy Awards in 2000.
In 2005, the comic was made captain on the Channel 4 show 8 Out Of 10 Cats, going on to appear in 18 series. He also appeared in Have I Got News For You and They Think Its All Over.
Comedians leading the tributes to Lock include Dara Ó' Brian.
"This is desperately sad news", the Mock The Week host tweeted. "Such a brilliantly funny man".
UK based Dublin comedian Catherine Bohard also wrote, "Sean Lock, what a loss".
David O'Doherty who co-starred alongside Sean Lock on 8 Out Of 10 Cats Does Countdown also said, "Rest in peace Sean Lock. A true natural comedian who taught me so much x".
Jarlaith Regan who presents An Irishman Abroad wrote this.
The show's host Jimmy Carr added, "Brutal news about Sean Lock today. I loved him. I’m watching clips of him right now - laughing & crying. I’ll miss him so much".
While another co-star from the show Jon Richardson also paid an emotional tribute to the late comic.
Let's remind ourselves just why Sean Lock was a much loved and very funny comedian.
