The movie which hits the US cinema screens on November, will be directed by Eastwood, 94, and will star British actor Nicolas Hoult as Justin Kemp, a family man who is serving as a juror in a high profile murder case.
In the movie, Hoult's character Kemp is "struggling with a serious moral dilemma - one he could use to sway the jury verdict and potentially convict or free the wrong killer".
Juror#2 also features JK Simmons, Toni Collette, Zoey Deutch, Gabriel Basso, Chris Messina, Cedric Yarbrough. Kiefer Sutherland. and Leslie Bibb.
The movie will receive its world premiere on the final night of the AFI Fest at the TCL Chinese Theatre on October 27.
Paying tribute to Eastwood, AFI president and CEO Bob Gazzale said this: "There is only one Clint Eastwood - and AFI is proud to present the world premiere of this next chapter in his historic canon".
"We are honoured to bring the community together once again - artists and audiences - to celebrate an American icon".
It was also reported that Eastwood's latest movie would be "a part of this year's awards race, and that chatter will only increase now that it is opening during the heart of awards season and playing at AFI, just like his Oscar contenders American Sniper and Richard Jewell".
